Analysis on the correlation between the stability of carotid atherosclerostic plaque and serum insulin-like growth factor-1 in patients with acute cere-bral infarction
- VernacularTitle:急性脑梗死患者颈动脉粥样硬化斑块稳定性与血清胰岛素样生长因子-1的相关性分析
- Author:
Feng TAO
1
;
Songbin HE
Author Information
1. 浙江省绍兴第二医院心内科
- Keywords:
Acute cerebral infarction;
Carotid atherosclerostic plaque;
Stability;
Serum insulin-like growth factor-1 (IGF-1)
- From:
China Modern Doctor
2015;(19):39-41,45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between the stability of carotid atherosclerostic plaque and serum in-sulin-like growth factor-1 (IGF-1) in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction who were admitted to our hospital from January 2012 to January 2014 were selected as an observa-tion group, and 50 healthy volunteers who received physical examination in our hospital at the same period of time were selected as a control group. ELISA method was applied to measure the level of serum IGF-1 in subjects, and carotid color ultrasonography was applied for examination in subjects. On the basis of the results of examination, the subjects were divided into stable plaque group, instable plaque group and plaque-free group. Results The detection rate of in-stable plaque, stable plaque, plaque-free and total plaque detection rate in the observation group were 42.0%, 25.0%, 33.0% and 67.0% respectively, in the control group were 8.0%, 18.0%, 74.0% and 26.0%. The differences were statis-tically significant (P<0.05). Serum IGF-1 level in the plaque-free group was significantly higher than that in the stable plaque group, and serum IGF-1 level in the plaque-free group and stable plaque group was significantly higher than that in the instable plaque group. The differences were statistically significant (P<0.05). One-way analysis of variance was applied in the comparison between multiple groups, F=4.158, P=0.006. The differences of neurological function and mental states before the treatment in the stable plaque group and instable plaque group were not statistically signifi-cant (P>0.05), and the neurological function and mental states after the treatment in the stable plaque group were signif-icantly better than those in the instable plaque group. The differences were statistically significant (P<0.05). Conclusion Patients with cerebral infarction have relatively higher incidence of carotid atherosclerostic plaque, and patients with stable carotid atherosclerostic plaque have higher serum IGF-1 level. The reduction of serum IGF-1 level is closely correlated with the formation of instable carotid atherosclerostic plaque.
