Clinical value of tests of plasma BNP and troponin I for elderly patients with sepsis
- VernacularTitle:老年脓毒症患者血浆BNP和肌钙蛋白I检测的临床价值
- Author:
Zhirong NG ZHA
1
;
Qiang LI
Author Information
1. 浙江中医药大学附属第一医院重症医学科
- Keywords:
The elderly;
Sepsis;
Type B natriuretic peptide;
Troponin I
- From:
China Modern Doctor
2015;(19):19-21,25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of tests of plasma type B natriuretic peptide (BNP) and troponin I (TnI) for elderly patients with sepsis. Methods A total of 108 elderly patients with sepsis who were admitted and treated in our department from January 2011 to January 2014 were selected. They were assigned to three groups according to the disease severity, 64 patients with common sepsis were as group A, 32 patients with severe sepsis were as group B, and 12 patients with septic shock were as group C. After being admitted to our department, mass concentration of plas-ma BNP and TnI for all patients were tested immediately. LVEF value of patients was tested by ultrasonic cardiogram, and APACHE II score was calculated. 28-day survival conditions for patients in group B and group C were followed up, each index between surviving patients and dead patients and connections between scores of BNP, TnI and APACHEIIwere compared. Results TnI and BNP for patients in group A were (0.08±0.01)μg/L and (206.42±76.15) pg/mL re spectively, in group B were (0.53±0.01) μg/L and (386.38±84.96) pg/mL respectively, in group C were (1.94±0.04) μg/L and (958.84±135.23) pg/mL respectively. The differences of mass concentrations of plasma BNP and TnI among the three groups were statistically significant (P<0.05). The more severe the disease conditions, the higher the mass con-centrations of plasma BNP and TnI. TnI and BNP for patients in the survival group were (0.47±0.08) μg/L and (692.59±22.17) pg/mL respectively, APACHEII was scored as (19.5±5.2), and LVEF was (52.1±13.9)%, while in the dead group were (1.23±0.05) μg/L, (986.25±22.65) pg/mL, (23.1±6.1) Scores, (41.5±11.5)%. The scores of BNP, TnI and APACHEII in dead group were significantly higher than those in the surviving group, and LVEF in dead patients was significantly lower than that in the survival group, the differences were statistically significant (P<0.05). Conclusion Mass concentration of plasma BNP and TnI can be used as effective indices for disease evaluation and prognosis for el-derly patients with sepsis.
