Expression and clinical significance of Cyclin E, p27 and Ki-67 proteins in patients with intracranial tumors
- VernacularTitle:Cyclin E、p27及Ki-67蛋白在颅内肿瘤患者中的表达及临床意义
- Author:
Lingli WU
1
;
Saiyan JIN
;
Guoping PENG
;
Dawei CUI
Author Information
1. 杭州市肿瘤医院检验科
- Keywords:
Intracranial tumors;
Cyclin E;
p27;
Ki-67
- From:
China Modern Doctor
2015;(19):5-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore expression and clinical significance of Cyclin E, p27 and Ki-67 proteins in patients with intracranial tumors. Methods All 46 cases of patients with intracranial tumor as tumor groups,normal brain tissues adjacent to intracranial tumor tissues as control groups. These samples were detected for the expression of Cyc lin E,p27,and Ki-67 by immune histochemical method(IHC)method. Positive rates of the three proteins in two groups,and the relationship between expressions of the proteins and pathological features of intracranial tumors were analyzed in this study. Results Cyclin E and Ki-67 expressions in tumor tissues were significantly higher than those in the control group(P<0.05),but p27 expression in tumor tissues was lower than the control groups (P<0.05). Cyclin E and Ki-67 positive rates in malignant tumor patients and the Ⅲ~Ⅳ grades with high deterioration were notably higher than those in benign tumors andⅠ~IIgrade with lower deterioration(P<0.05),p27 expression rates were lower andⅠ~IIat lower deterioration of benign tumors(P<0.05). Conclusion Higher expressions of Cyclin E and Ki-67,and low expression of p27 may be important factors involved in the occurrence and development of intracranial tumors, and positive expres-sions of Cyclin E,p27 and Ki-67 are related to the features and degree of differentiation of the intracranial tumors.
