A study on the curative effects of hydroxychloroquine sulphate combined with tacrolimus in the treatment of oral lichen planus
- VernacularTitle:硫酸羟氯喹联合他克莫司治疗口腔扁平苔藓的疗效研究
- Author:
Lian FENG
1
;
Zhongxian LI
;
U Y LIU
Author Information
1. 广东省梅州市人民医院口腔科
- Keywords:
Oral lichen planus;
Tacrolimus;
Hydroxychloroquine sulphate
- From:
China Modern Doctor
2015;(16):68-70
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the short-term curative effects and safety of conventional immunosuppressor (hydrox-ychloroquine sulphate) combined with tacrolimus in the treatment of oral lichen planus. Methods Eighty patients with oral lichen planus were assigned to two groups. The experiment group was sublingually given 0.0015%of tacrolimus so-lution twice a day, and was orally given 100 mg of hydroxychloroquine sulphate tablets once a day. The control group was orally given 100 mg of hydroxychloroquine sulphate tablets once a day. The treatment was observed for 4 weeks, and the effective rate and incidence of adverse effects at the end of the treatment were evaluated. Results The effective rate of experiment group was 95.0%, and the control group was 35.0%. The short-term curative effect of hydroxychloro-quine sulphate combined with tacrolimus in the treatment of oral lichen planus was significantly better than that of hydroxychloroquine sulphate alone (χ2=31.65, P=0.00), but the incidence of adverse had not significantly different be-tween two groups. Conclusion The short-term curative effect of hydroxychloroquine sulphate combined with tacrolimus in the treatment of oral lichen planus is significantly better than that of hydroxychloroquine sulphate alone, which is safe and effective, and is worthy of clinical promotion and application.
