Review of fatty acid synthase inhibitor and its anti-tumor effect
- VernacularTitle:脂肪酸合成酶抑制剂及其抗肿瘤作用研究进展
- Author:
Yijing CHEN
1
;
Houde ZHANG
Author Information
1. 广东医学院
- Keywords:
Fatty acid synthase inhibitor;
Orlistat;
Anti-tumor effect
- From:
China Modern Doctor
2015;(15):152-155
- CountryChina
- Language:Chinese
-
Abstract:
It has been proved that FAS is a potent oncogene. Its expression and activity is normal in most of the non-neoplastic cells, but it is over-expressed and associated with poor prognosis in several human malignancies. Recent studies show that FAS inhibitor can induce significant anti-tumor effect. It reduces cell proliferation,enhances apopto-sis,inhibits tumor invasion and metastasis,while it is also an chemosensitization for other chemotherapy drugs. In this paper, the anti-tumor mechanism of FAS inhibitors is reviewed to prospect the research direction of its anti-tumor ef-fect.
