Changes of coagulation function and factor analysis for patients taking hemodialysis
- VernacularTitle:血液透析患者凝血功能变化及因素分析
- Author:
Fen LIAN
1
;
Gefei CHEN
;
Dongmei ZHAO
;
Yan YU
Author Information
1. 浙江省丽水市人民医院血液净化科
- Keywords:
Hemodialysis;
Coagulation function;
Cause
- From:
China Modern Doctor
2015;(15):83-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of hemodialysis on patients' coagulation function and to analyze its rea-sons. Methods Blood samples of 68 patients before and after hemodialysis who took maintenance hemodialysis in our hospital from January 2012 to April 2014 were selected. Flow cytometry was applied to test P-selectin on platelet sur-face. Indirect enzyme linked immunosorbent assay was applied to test ultra-sensitive C-reactive protein, endothelial von Willebrand factor and D-dimer. Through the observation on patients, arrangement of patient data, and measurement of dialyzer blood volume after hemodialysis, reasons and analysis for changes of coagulation function for patients taking hemodialysis were retrospectively analyzed. Results All patients were discharged from hospitals after the treatment, and PT and FIB values after the treatment were significantly lower than those before the treatment (P<0.05). APTT and TT values were not statistically different from those before the treatment (P>0.05). Positive rate of D-dimer was 50%before the treatment and 0.0% after the treatment, and the difference compared before and after the treatment was statistically significant (P<0.05). Results of P-selectin on platelet surface, ultra-sensitive C-reactive protein, endothelial von Wille-brand factor and D-dimer after hemodialysis were significantly higher than those before hemodialysis, and the differ-ences were statistically significant. Factors affecting changes of patients' coagulation function included individual health quality, doctors' inaccurate assessment, inappropriate anti-coagulation, insufficient usage of heparin and inappropriate operation techniques by nurses. Conclusion Medical staff should enhance their knowledge of anti-coagulation, improve the assessment and testing of coagulation status for patients taking hemodialysis, provide anti-coagulation protocol timely and properly, and practice operation techniques. Meanwhile, although heparin is used during treatment, patients may still be highly coagulated. Therefore, regular monitoring of coagulation indicators is able to effectively reduce co-agulation during hemodialysis.