Effect of Tripterygium glycosides combined with Irbesartan on podocyte injury in diabetic nephropathy
- VernacularTitle:雷公藤多苷联合厄贝沙坦对糖尿病肾病患者足细胞损伤的影响
- Author:
Jianlin LIU
1
;
Mingliang CHEN
;
Hui LI
;
Huichao WANG
;
Wei ZHANG
Author Information
1. 河南大学第一附属医院肾内科
- Keywords:
Tripterygium glycosides;
Diabetic nephropathy;
Podocyte
- From:
China Modern Doctor
2015;(15):76-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss effect of Tripterygium glycosides combined with Irbesartan on podocyte injury in dia-betic nephropathy. Methods All 80 cases with diabetic nephropathy were selected as subjects, and were divided into group A, group B, group C and group D. Based on active control of blood sugar and other treatment,group A was treated with Tripterygium glycosides combined with Irbesartan, group B was treated with Tripterygium glycosides, and group C was treated with Irbesartan. Sufficient number of cells,and urinary CTGF,TGF-β,OPN,BMP-7 concentra-tion were compared. Results After treatment,proteinuria, podocyte number,CTGF,TGF-β, OPN of four group were decreased apparently,and BMP-7 was increased(P all约0.01 or 0.05). Proteinuria,podocyte number,CTGF,TGF-β,OPN of group A,B,C were lower than group D,and BMP-7 was higher than group D(P all<0.01). Urinary podocyte number and urine protein were positively correlated with each other, and urinary podocyte number and urine protein were positively correlated with CTGF, TGF-β,OPN, negative correlated with BMP-7 (P all <0.01). Conclusion Tripterygium glycosides combined with Irbesartan for diabetic nephropathy has a role in protecting the kidney podocytes.
