Clinical manifestations analysis of amiodarone-induced adverse reactions in our hospital from 2008 to 2014
- VernacularTitle:我院2008~2014年胺碘酮不良反应的临床表现分析
- Author:
Geng PENG
1
;
Wenyan XIE
Author Information
1. 漯河医学高等专科学校第一附属医院 漯河市中心医院心内科
- Keywords:
Amiodarone;
Adverse drug reactions;
Clinical manifestations
- From:
China Modern Doctor
2015;(15):70-72,75
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the occurrence characteristics and related factors of amiodarone-induced adverse re-actions (ADR)in our hospital so that we can provide reference for clinical safety,rational drug use. Methods Amio-darone-induced ADR reports of inpatient and outpatient in our hospital from January 2008 to June 2014 were collected,and amiodarone-induced ADR clinical manifestations, treatment and outcome and other information were statistically analyzed. Results In amiodarone-induced ADR reports of the reported 120 cases in our hospital, ADR proportions of men and people with advanced age, original cardiovascular diseases or injections, were slightly high ,and there was a low incidence of severe ADR (16.67%). The main clinical manifestations were liver damage (36.67%), phlebitis(30.83%),allergic-like reactions and anaphylactic shock(11.67%),rash(7.50%),hypotension and arrhythmias(5.83%),thyroid dysfunction (4.17%) and lung damage (3.33% ). After drug reduction, drug withdrawal, active clinical treat ment and other treatments, 35 cases (29.17%) cured and 76 cases (63.33%) improved, with 8 cases (6.67%) of sequelae and 1 case of death (0.83%). Conclusion Amiodarone is a kind of relatively safe antiarrhythmic drugs, but its ADR manifestations are various. We should restrict indications and closely monitor ADR in order to reduce the oc-currence of serious adverse events in clinical work.
