Observation of the curative effect of temozolomide combined with radio-therapy in the treatment of malignant gliomas
- VernacularTitle:替莫唑胺联合放疗同步治疗胶质母细胞瘤的疗效观察
- Author:
Chongren WANG
1
;
Xin XU
;
Yu YOU
;
Lei HAN
;
Sijun ZHAO
;
Ming ZHAO
Author Information
1. 郑州大学附属肿瘤医院神经外科
- Keywords:
Malignant glioma;
Temozolomide;
Combined with radiotherapy;
Synchronization treatment;
Quality of life
- From:
China Modern Doctor
2015;(15):67-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of temozolomide combined with radiotherapy in the treatment of malignant gliomas. Methods A total of 64 patients with pathologically confirmed glioblastoma received radiotherapy combined with chemotherapy in our hospital from January 2008 to January 2014, radiotherapy synchronized with TMZ chemotherapy were used in 39 patients (synchronized group) and radiotherapy sequential with TMZ chemotherapy in 25 patients (sequential group).1 year and 3 year survival rates, response rate and drug safety were compared between the two groups. Results The patients were followed up for 6 months to 3 years, the synchronous group of patients 1 years and 3 years survival rates (74.4%, 38.5%) were higher than the sequential group(64.0%, 28.0%) (P<0.05), objective re-sponse rate of two groups were 64.1%and 44.0%, the difference was statistically significant(P<0.05), gastrointestinal re-action rates of two groups were 23.1% and 20.0%, the difference was not statistically significant (P>0.05). Adverse re-actions were statistically significant (P<0.05). Conclusion The effect of radiotherapy synchronized combined with TMZ chemotherapy is better than radiotherapy sequential with TMZ chemotherapy for glioblastoma, it is still the first choice for the treatment of glioblastoma although the clinical manifestations of toxicity increased than the sequential group.
