An analysis on the clinical effects of aripiprazole on post-schizophrenic depression
- VernacularTitle:阿立哌唑在精神分裂症后抑郁中的临床疗效分析
- Author:
Zhengping CHEN
1
;
Yongxiu YANG
Author Information
1. 浙江省绍兴市第七人民医院精神科
- Keywords:
Aripiprazole;
Schizophrenia;
Depression;
Life quality
- From:
China Modern Doctor
2015;(15):60-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effects of aripiprazole on post-schizophrenic depression and its effects on patients' life quality. Methods A total of 82 patients with post-schizophrenic depression who were admitted to our hos-pital from January 2011 to July 2014 were selected as research subjects. They were randomly assigned to control group(n=41)and experiment group(n=41). The control group was given risperidone, and the experiment group was given aripiprazole. Changes of PANSS scores, HAMD scores, CGI scores and QOL-100 scores between the two groups were compared. Results PANSS scores, HAMD scores, CGI scores and QOL-100 scores between groups before the treatment were not statistically different(P>0.05). After the treatment, scores in the two groups improved significantly compared to those before the treatment, and the differences were statistically significant(P<0.05). Psychopathology score in the experiment group 24 weeks after the treatment was lower than that in the control group. Scores of negative symptom scale and HAMD scores 12 weeks and 24 weeks after the treatment were both lower than those in the control group. CGI score 12 weeks after the treatment was lower than that in the control group. QOL-100 scores was higher than that in the control group. The differences were all statistically significant (P<0.05). Differences of adverse events were not statistically significant(χ2=0.179, P>0.05). Conclusion After the treatment of aripiprazole for patients with post-schizophrenic depression, depression and negative symptoms are improved greatly, and the life quality is enhanced.
