Curative effect of somatostatin on acute adhesive intestinal obstruction and its protection effect on intestinal mucous membrane barrier function
- VernacularTitle:生长抑素治疗急性粘连性肠梗阻的疗效及对肠黏膜屏障功能的保护作用
- Author:
Liang XU
1
;
Shengliang CHI
Author Information
1. 浙江省天台县人民医院普外科
- Keywords:
Acute adhesive intestinal obstruction;
Somatostatin;
Endotoxin;
Diamineoxidase(DAO);
Procalcitonin(PCT)
- From:
China Modern Doctor
2015;(15):57-59,63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss curative effect of somatostatin on acute adhesive intestinal obstruction and its protec-tion effect on intestinal mucous membrane barrier function. Methods All 90 cases of patients with acute adhesive in-testinal obstruction were divided into two groups, with 45 cases of patients in research group and control group respec-tively. The patients in control group were given routine medical treatment, such like fasting, water-fast, continuous gas-trointestinal decompression, antibiotics to prevent infection, relieving spasm and pain, adjustment of water-electrolyte imbalance, total parenteral alimentation(TPA)and etc. The patients in research group were additionally given 3 mg so-matostatin injection, 50 mL normal saline(NS) with minipump by 4 to 6 mL per hour, until cacation or exhaust from anus, given transit operation treatment or termination of treatment, while the patients in control group were given the same medical treatment as that in research group except for somatostatin. The changes of serum endotoxin, diamineoxi-dase (DAO)and procalcitonin(PCT)levels of patients in two groups before and 5 days after medical treatment were ob-served and compared, and the clinical curative effect and untoward effect were evaluated as well. Results After 5 days'medical treatment, the serum endotoxin, DAO and PCT levels of patients in two groups were obviously declined than before (P<0.05 or P<0.01), and the declining rate of patients in research group was much higher than that in control group(P<0.05), and meanwhile, the total clinical efficiency of patients in research group(95.56%)was much higher than that in control group(80.00%)(χ2=5.07, P<0.05). 3 cases(6.67%)and 5 cases(11.11%)of untoward effect were appeared on patients in control group and research group during treatment, and no statistical differences were appeared after comparison(χ2=0.14, P>0.05). Conclusion The somatostatin has reliable curative effect on adhesive intestinal ob-struction after abdominal operation, and can obviously improve clinical symptom with high security, whose mechanism of action may have close effect on reducing serum endotoxin, DAO and PCT levels and protecting and repairing in-testinal mucous membrane barrier function.
