The study of effect of levonorgestrel intrauterine system on the expres-sions of insulin-like growth factor-1 with endometrial polyps
- VernacularTitle:子宫内膜息肉术后放置左炔诺孕酮宫内释放系统对IGF-1的影响研究
- Author:
Yueping TAO
1
;
Xiaojie WU
Author Information
1. 浙江省嘉兴市妇幼保健院妇科
- Keywords:
Endometrial polyps;
Levonorgestrel intrauterine system;
Insulin-like growth factor-1
- From:
China Modern Doctor
2015;(15):31-33,36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study levonorgestrel intrauterine system on insulin-like growth factor-1 (IGF-1) in endometri-um tissue for patients with endometrial polyps. Methods All 182 patients with endometrial polyps in our hospital from January 2010 to December 2011 were selected as research object, and randomly divided into control group(routine treatment group)94 cases and observation group(levonorgestrel intrauterine system in uterus group)88 cases. The IGF-1 expression of endometrial biopsy specimens during intraoperative and rechected after 6 months were measurd by im-munohistochemistry. Patients were followed up for 2 years to analyse endometrial polyp recurrence. Results The ex-pressions of IGF-1 decreased significant in endometrium tissue of observation group with operation. But there were no significant differences in control group. Followed up for 2 years, the endometrial polyp recurrence was 8.05% in control group and without recurrence in study group. Conclusion Levonorgestrel intrauterine system may be involved in the in-hibiting of the expression of IGF-1 then to induce the recurrence of endometrial polyps.
