The effect of gingkgo biloba extra on spatial learning-memory in rats with chronic hypoxic hypercapnia
- VernacularTitle:银杏叶提取物对慢性低O2高CO2大鼠空间学习记忆的影响
- Author:
Songfang CHEN
1
;
Shengmin SHAO
;
Beilei HU
;
Zhiyong HE
;
Xiaotong WANG
;
Yongsheng GONG
;
Hongyu ZHOU
Author Information
1. 温州医科大学附属第二医院 育英儿童医院神经内科
- Keywords:
Chronic hypoxic hypercapnia;
Gingkgo biloba extra;
Praxiology;
Morris water maze
- From:
China Modern Doctor
2015;(15):1-3,10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe changes of spatial learning-memory in rats with chronic hypoxic hypercapnia and the effect of gingkgo biloba extra. Methods After established the rat model of chronic hypoxic hypercapnia,seventy-two rats were randomly divided into four groups normal control (NC),hypoxic-hypercapnia 4-week (4HH),hypoxic-hy-percapnia 4-week+gingkgo biloba extra (EGb)high dose(100 mg/kg)group[4HH+EGb(H)] and hypoxic-hypercapnia 4-week+EGb low dose (50 mg/kg) group[4HH+EGb(L)]. Praxiology in rats was asessed by the Morris water maze and step down test. Results The spatial learning-memory in rats exposed to chronic hypoxic-hypercapnia 4-week(4HH group)were displayed significant impairment in their performance,the longer mean escape latencies and swim path dis tances,the more error times. 4HH+EGb(H) and 4HH+EGb(L)groups shortened the reaction time of leaning, pro longed the latent time of memory, reduced times of mistakes. Conclusions EGb can enhance the capacity of learning-memory in the rats exposed chronic hypoxic hypercapnia.
