Changes and significance of CEA and CA-199 before and after radiother-apy and chemotherapy for advanced gastric cancer
- VernacularTitle:晚期胃癌放化疗前后CEA、CA-199变化及意义
- Author:
Zhongzhu TANG
1
;
Guan LIU
;
Lie WU
;
Dong LIU
;
Xiao ZHENG
Author Information
1. 浙江省肿瘤医院放疗科
- Keywords:
Advanced gastric cancer;
Radiotherapy and chemotherapy;
Carcino-embryonic antigen (CEA);
Carbohydrate antigen-199 (CA-199);
Specificity
- From:
China Modern Doctor
2015;(14):7-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of carcino-embryonic antigen (CEA) and carbohydrate antigen-199 (CA-199) before and after radiotherapy and chemotherapy in patients with local advanced gastric cancer, and to analyze the significance of the changes. Methods A total of 38 patients with local advanced gastric cancer who received radiotherapy and chemotherapy in our hospital from July 2003 to June 2011 were selected, and another 38 healthy subjects who received physical examination in our hospital at the same period of time were randomly selected. CEA and CA-199 levels of patients with gastric cancer before and after radiotherapy and chemotherapy, as well as the levels of healthy subjects were measured respectively. Venous blood samples were collected for all subjects at early morning under fast-ing condition, and the blood samples were tested by electro-chemiluminescence before gastric cancer was diagnosed by levels of CEA and CA-199 indices. Results The levels of CEA and CA-199 in patients with advanced gastric cancer were higher than those in the healthy subjects. After radiotherapy and chemotherapy, levels of CEA and CA-199 signifi-cantly reduced, and significantly lower than those before radiotherapy and chemotherapy. Accuracy, specificity and sen-sitivity of CEA were 91.67%, 96.67% and 86.67% respectively, and accuracy, specificity and sensitivity of CA-199 were 76.67%, 83.33% and 76.00% respectively. Total positive rate for all patients after radiotherapy and chemother-apy reduced to 42.11%(16/38). Total positive rate for patients with decreased CEA was lower, and 3-year total survival rate was higher. The total positive rate for patients with decreased CA-199 was lower, and the disease free survival rate and 2-year total survival rate were both higher, the differences were statistically significant (P<0.05 for both). Con-clusion The levels of CEA and CA-199 significantly reduce after radiotherapy and chemotherapy for patients with local advanced gastric cancer, and the accuracy of CEA and CA-199 for diagnosing local advanced gastric cancer is high. The possibilities of poor prognosis significantly rise when levels of CEA and CA-199 after radiotherapy increase. The levels of CEA and CA-199 after the treatment are positively correlated with the proportion of positive patients, disease free survival rate and 3-year survival rate.
