Pathogenesy and research advancement of myocardial fibrosis
- VernacularTitle:心肌纤维化的发病机制及其研究进展
- Author:
Rui YU
1
;
Youping WANG
;
Lin CUI
;
Bin LI
;
Shiyang XIE
;
Yuan GAO
;
Xinlu WANG
;
Mingjun ZHU
Author Information
1. 河南中医学院第一附属医院心脏中心
- Keywords:
Myocardial fibrosis;
Extracellular matrixc;
AngiotensinII;
Aldosterone;
Cell factor;
Oxidative stress and inflamatory factors
- From:
China Modern Doctor
2015;(13):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial fibrosis is featured by excessive proliferation of cardiac fibroblast and collagen deposition. There is close relationship between myocardial fibrosis and various cardiovascular disease, and it is potential risk factor for sudden death. At present the precise mechanism remains unclear.Myocardial fibrosis has been found to relate with renin-angiotensin-aldosterone system,cell factor,oxidative stress,inflamatory factor,endothelial function obstacles,Intracellular calcium ion. These factors influences the occurrence of myocardial fibrosis by the same or different pathway.
