Effects of preoperative regional intra-arterial infusion chemotherapy for patients with advanced gastric cancer
- VernacularTitle:区域性动脉灌注新辅助化疗对进展期胃癌治疗的研究
- Author:
Xinrong SUN
1
;
Lianjin QIN
;
Chengwu TANG
;
Wenming FENG
;
Ying BAO
;
Maoyun FEI
;
Yinyuan ZHENG
;
Peifeng ZHU
Author Information
1. 湖州师范学院附属第一医院普外科
- Keywords:
Gastric carcinoma;
Neoadjuvant chemotherapy;
Arterial infusion
- From:
China Modern Doctor
2015;(13):81-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of preoperative regional intra-arterial infusion chemotherapy for patients with advanced gastric cancer (AGC). Methods A total of 82 patients with clinical stage Ⅲ,Ⅳ gastric cancer received two cycles of neoadjuvant regional intra-arterial infusion chemotherapy (arterial infusion group, n=42) or neoadjuvant systemic chemotherapy (systemic chemotherapy group, n=40). The operation was administrated in 10 to 15 days before chemotherapy. All patients received 6 course of systemic chemotherapy after surgery. Chemotherapy toxicity and sur-vival rate were retrospectively analyzed. Results No significant difference was found in chemotherapy toxicity between two groups. The median survival period was 25.3 months in arterial infusion group and 19.1 months in systemic chemotherapy group. 3-year survival rate was 36.4% in arterial infusion group and 21.0% in systemic chemotherapy group respectively, there were significant differences (P<0.05). Conclusion Preoperative regional intra-arterial infusion chemotherapy is well tolerated in advanced gastric cancer patients and could improve short-term survival.
