Analysis of pathogens and clinical characterization of hand, foot and mouth disease in Huzhou city from 2013 to 2014
- VernacularTitle:2013~2014年湖州市手足口病病原和临床特征分析
- Author:
Qiuling HUANG
1
;
Ye WU
;
Jiawei WANG
;
Zhen XU
;
Zhiqiang JIANG
;
Min GAO
;
Dawei CUI
;
Yu CHEN
;
Xiang WANG
Author Information
1. 浙江省湖州市中心医院儿科
- Keywords:
Hand,foot and mouth disease;
Enterovirus 71;
Coxsackie A16
- From:
China Modern Doctor
2015;(13):44-46,49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the pathogens and clinical characterization of hand,foot and mouth disease (HFMD)in Huzhou city from 2013 to 2014. Methods All 253 specimens included 208 stool specimens and 45 throat swabs,and clinical data from 208 children cases with hand,foot and mouth diseases (HFMD)were collected. Preliminary de-tection for all of the specimens was performed by one-step triple real-time RT-PCR assay. Results Real-time RT-PCR assay indicated that the positive rate of Enterovirus(EV)from 208 cases was 83.17%(173/208),and the percent-ages of EV71,CoxA16 and other's EV subtypes in 173 enteroviruses were 55.49%,13.29%and 31.21%,respectively. These results were not significant differences between male and female children. EV71 from children with HFMD was predominant strain below 5 old years (≤5),and other's EV subtypes were predominant strains over 5 years (>5). Of fever with herpes was main clinical symptom in patients with HFMD,and EV71 was primary enterovirus induced many clinical features, such as fever with herpes or vomiting or neurological symptoms and so on. Additionally, detection rate of EV in stool specimens was significant higher than that in throat swabs. Conclusion EV71 and other's EV sub-types are predominant strains, CoxA16 strains have a downtrend in patients with HFMD in Huzhou city, so that the medical workers should improve the ability of surveillance to EV,EV71 and CoxA16 in order to make better for control and prevention of the HFMD diseases.
