Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms.
- Author:
Eun Ran KIM
1
;
Mun Hee YANG
;
Yeun Jung LIM
;
Jin Hee LEE
;
Dong Kyung CHANG
;
Young Ho KIM
;
Hee Jung SON
;
Jae J KIM
;
Jong Chul RHEE
;
Jin Yong KIM
Author Information
1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. jinyong33.kim@samsung.com
- Publication Type:Original Article
- Keywords:
Plasminogen activator inhibitor 1;
Colorectal neoplasms
- MeSH:
Adenoma;
Colonoscopy;
Colorectal Neoplasms;
Mass Screening;
Medical Records;
Multivariate Analysis;
Neoplasm Metastasis;
Odds Ratio;
Plasma;
Plasminogen;
Plasminogen Activator Inhibitor 1;
Plasminogen Activators;
Prevalence
- From:Gut and Liver
2013;7(5):519-523
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Plasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas. METHODS: We reviewed the medical records of 3,136 subjects who underwent colonoscopy as a screening exam. The subjects were classified into a case group with adenomas (n=990) and a control group (n=2,146). Plasma PAI-1 levels were categorized into three groups based on tertile. RESULTS: The plasma levels of PAI-1 were significantly higher in adenoma cases than in controls (p=0.023). The prevalence of colorectal adenomas increased significantly with increasing levels of PAI-1 (p=0.038). In the adenoma group, advanced pathologic features, size, and number of adenomas did not differ among the three groups based on tertiles for plasma PAI-1 levels. Using multivariate analysis, we found that plasma level of PAI-1 was not associated with the risk of colorectal adenomas (p=0.675). Adjusted odds ratios for colorectal adenomas according to increasing plasma levels of PAI-1 were 0.980 (95% confidence interval [CI], 0.768 to 1.251) for the second-highest plasma level and 1.091 (95% CI, 0.898 to 1.326) for the highest level, compared with the lowest levels. CONCLUSIONS: These results suggest that elevated plasma PAI-1 levels are not associated with the risk of colorectal neoplasms.
