Comparison of domestic and imported aspirin and clopidogrel on MPA, PRI of patients with coronary heart disease for angina pectoris
- VernacularTitle:国产与进口阿司匹林和氯吡格雷治疗心绞痛对患者MPA、PRI的影响对比
- Author:
Yanhong GAO
1
;
Chunsheng LI
;
Junqiang YUAN
Author Information
1. 河南省信阳市中心医院心内科
- Keywords:
Aspirin;
Clopidogrel;
Angina pectoris;
Platelet aggregation rate;
Platelet response index
- From:
China Modern Doctor
2015;(13):12-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of platelet aggregation rate, platelet response index in patients with coronary heart disease by domestic and imported aspirin and clopidogrel and its safety. Methods The date of 100 cases patients with coronary heart disease for angina pectoris from November 2012 to November 2013 were retrospectively analyzed in this study, according to different drug sources, they were divided into import group and domestic group, 50 cases each. Import group was treated with imported aspirin and clopidogrel, the domestic group was treated with domestic aspirin and clopidogrel. MPA, PRI before medication, medication discontinuation after 1, 2 weeks and 6 h, 12 h and 1 d after discontinuation between two groups were compared, treatment of cardiovascular and adverse drug reactions occur within 1 year were observed. Results There was no significant difference between two groups for MPA and PRI before treatment (P>0.05); MPA, PRI after treatment 1 week, 2 weeks in import group were lower than that in domestic group (P<0.05). 6 h after the drug was stopped, MPA had no difference between two groups (t=1.209, P=0.229>0.05), 12 h and 1 d after drug withdrawal, MPA in import group were higher than that in domestic group ( P<0 . 05 ); Discontinuation after 6 h , 12 h , PRI in domestic group were significantly higher than that in import group (P<0.05), after the withdrawal of 1 d, there was no statistical significance (t=1.332, P=0.186>0.05). The incidence of cardiovascular adverse events in import group were lower than that in the domestic group, with statistically significant differences (P<0.05). Team rash, abdominal pain, bruising rates in import group were lower than that in domestic group, the differences were statistically significant (P<0.05). Conclusion Compared with domestic, aspirin combined with clopidogrel plays a positive and effective role in resistting platelet clotting in patients with coronary heart disease for angina pectoris, and platelet function can be quickly restored after the drug is stopped, can significantly reduce the recurrence of myocardial infarction, angina pectoris, heart cerebrovascular accident prevention, reduce mortality.
