The expression and significance of serum IL-27 and TGF-β1 in patients with pulmonary fibrosis
- VernacularTitle:IL-27与TGF-β1在肺纤维化患者血清中的表达及意义
- Author:
Xiaodong YANG
1
;
Xuemei MA
;
Yunhui SUN
;
Wenhua BAO
Author Information
1. 佳木斯大学附属第一医院呼吸内科
- Keywords:
IL-27;
TGF-β1;
Pulmonary fibrosis
- From:
China Modern Doctor
2015;(13):9-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of IL-27 and TGF-β1 in patients with pulmonary fibrosis. Methods The expression levels of IL-27 and LTB4 were determined by ELISA method in 20 cases of pulmonary fibrosis patients and 15 cases of healthy control group. Results(1)The levels of IL-27 and TGF-β1 in pul-monary fibrosis patients were higher than the control group;IL-27 and TGF-β1 levels were gradually increased from the control group, pulmonary fibrosis mild hypoxia group, moderate hypoxia group, severe hypoxia group, the differences were statistically significant (F=21.58, P<0.001; F=18.75, P<0.001);(2)The serum IL-27 and TGF-β1 levels were significantly reduced with the increase of PaO2, the linear correlation was found between the two groups and PaO2 were negatively correlated(r=-0.754,P<0.05;r=-0.793,P<0.05);It was positively correlated between IL-27 and TGF-β1(r=0.854,P<0.05). Conclusion IL-27 and TGF-β1 were being involved in the pathogenesis of pulmonary fibrosis, detec-tion simultaneously, there were important significances for pulmonary fibrosis clinic diagnosis and therapy.
