Detection of serum carbohydrate antigen 153 and human epididymis pro-tein 4 in the cervical cancer patients
- VernacularTitle:糖链抗原153与人附睾分泌蛋白4在宫颈癌患者血清中的表达
- Author:
Haiying WANG
1
;
Jinzhu GAO
;
Xuzhen HU
;
Xiaojie WU
Author Information
1. 浙江省嘉兴市秀洲区妇幼保健院妇产科
- Keywords:
CA153;
HE4;
Cervical cancer;
Combined detection
- From:
China Modern Doctor
2015;(13):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of serum carbohydrate antigen 153(CA153) and human epididymis protein 4 (HE4) in the cervical cancer patients. Methods 72 cases of cervix neoplasms patients received from Jun 2010 to July 2013,were divided into the cervical cancer group(36 cases)and cervical benign lesions group(36 cases)according to different pathological results, 36 cases of healthy women undergoing physical examination at the same time were chosen as control group. The level of serum CA153 and HE4 of above research subjects were detected and analyzed. Results The level of serum CA153 of cervical cancer group(79.6±14.8)U/mL was higher than that of cervical benign lesions group (t=5.17, P<0.05) and control group (t=7.31, P<0.05), there was statistically significant differ-ence; the level of serum HE4 of cervical cancer grou (216.3±8.1) pmol/L was higher that of cervical benign lesions group(t=9.71,P<0.05) and control group (t=11.84, P<0.05), there was statistically significant difference; the posi-tive rate of combined detection was higher than that of single detection, there was statistically significant difference(χ2=4.527,P<0.05); The level of serum CA153 and HE4 in III/IV stage were higher than that in I/II stage, and the difference was statistically significant (P<0.05). Conclusion The level of serum CA153 and HE4 of cervical cancer patients increase significantly. The combined detection of CA153 and HE4 can improve the diagnostic sensitivity,specificity and accordance rate of cervical cancer prominently,so it has great reference value in the early diagnosis and treatment of cervical cancer.
