Efficacy of panipenem combined sulbactam on vitro antibacterial activity of acinetobacter baumannii
- VernacularTitle:帕尼培南联合舒巴坦对鲍曼不动杆菌体外抗菌活性的研究
- Author:
Qian JIN
1
;
Dongguo WANG
Author Information
1. 浙江省台州市立医院感染科
- Keywords:
Acinetobacter baumannii;
Panipenem;
Sulbactam;
Checkerboard method
- From:
China Modern Doctor
2015;(13):1-4,8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the synergy effect of panipenem combined sulbactam on vitro antibacterial activity of acinetobacter baumannii. Methods Forty strains of panipenem-susceptible and panipenem resistant acinetobacter bau-mannii were randomly selected respectively, and the minimum inhibitory concentration (MIC) values of panipenem and/or sulbactam were determined using microbroth dilution method and checkerboard method. The fractional inhibitory in-dex (ΣFIC) were calculated, and then the vitro combination effect of panipenem and sulbactam were determined. Re-sults Compared with the single drug group, in the combination group of panipenem and sulbactam, the MIC50 and MIC90 of panipenem-susceptible acinetobacter baumannii decreased two times in dilution, while the MIC50 and MIC90 de-creased one times in dilution in panipenem-resistant strains. For the panipenem-susceptible strains, The combination of panipenem and sulbactam demonstrated 30.0% (12/40) synergism, 45.0% (18/40) partial synergism, 15.0%(6/40) addi tive, For the panipenem-resistant strains, the synergistic effect was 10.0%(4/40), partially synergistic effect was 57.5%(23/40), the additive effect was 22.5% (9/40), and indifference effect of the two groups was 10.0% (4/40). No strain had antagonistic effect. Conclusion In vitro tests, panipenem and sulbactam combination show synergism or partial syner-gism against most acinetobacter. baumannii isolates. Compared with the alone use, the combination of panipenem and sulbactam is more effective in inhibiting the growth of acinetobacter baumannii.
