Influence of octreotide on serum LPS and high sensitive C-reactive pro-tein (hs-CRP) levels for patients with early postoperative inflammatory intestinal obstruction
- VernacularTitle:奥曲肽对术后早期炎性肠梗阻患者血清内毒素和超敏C反应蛋白水平的影响
- Author:
Jiuhui WEN
1
;
Shiyun LUO
;
Zhongping XIA
;
Hongbin HUANG
;
Jianfeng CHEN
Author Information
1. 浙江省台州市肿瘤医院普外科
- Keywords:
Abdominal operation;
Early inflammatory intestinal obstruction;
Octreotide;
LPS;
High sensitive C-re-active protein
- From:
China Modern Doctor
2015;(12):84-86,89
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss curative effect of Octreotide on early inflammatory intestinal obstruction after abdomi-nal operation and its influence on serum LPS and High sensitive C-reactive protein (hs-CRP) levels. Methods All 64 cases of patients with early inflammatory intestinal obstruction after abdominal operation were selected and divided into observation group (n=32) and control group (n=32) at random. The patients in two groups were given routine medical treatment, such like fasting, instant gastrointestinal decompression, anti-infection, intravenous nutrition,maintenance of water-electrolyte and acid-base balance and etc. The patients in observation group were additionally given 0.1mg Octreotide by hypodermic injection,q8h,while the patients in control group were given the same medical treatment as that in observation group except for Octreotide. The changes of serum LPS and hs-CRP levels of patients in two groups before and 6 days after the medical treatment,and the curative effect and untoward effect was compared as well. Results After 6 days' medical treatment, serum LPS and hs-CRP levels of patients in two groups were obvi-ously declined than before(P<0.05 or P<0.01),and the declining rate of patients in observation group was much higher than that in control group (P<0.05), and the total clinical efficiency in observation group (93.75%) was much higher than that in control group (75.00%)(χ2=4.27,P<0.05). 1 and 3 cases of untoward effect were appeared on patients in control group and observation group during treatment with light symptom, and after comparing the occurrence rates of untoward effect of patients in two groups,no differences were appeared(χ2=0.27,P>0.05). Conclusion Octreotide has reliable curative effect on early inflammatory intestinal obstruction after abdominal operation with high security, whose mechanism of action has close effect on obvious reducing serum LPS and hs-CRP levels of patients.
