Sequential Therapy for Helicobacter pylori Infection in Korea: Systematic Review and Meta-Analysis.
- Author:
Joon Sung KIM
1
;
Byung Wook KIM
;
Joo Ho HAM
;
Hyung Wook PARK
;
Yun Kyeong KIM
;
Min Young LEE
;
Jeong Seon JI
;
Bo In LEE
;
Hwang CHOI
Author Information
1. Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea. gastro@catholic.ac.kr
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
Helicobacter pylori;
Eradication;
Meta-analysis
- MeSH:
Adult;
Electrolytes;
Helicobacter;
Helicobacter pylori;
Humans;
Intention;
Korea;
Odds Ratio
- From:Gut and Liver
2013;7(5):546-551
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Sequential therapy (ST) for Helicobacter pylori infection in countries other than Korea has shown higher eradication rates than triple therapy (TT). The aim of this study was to evaluate the efficacy of ST in Korea by performing a meta-analysis. METHODS: We performed a comprehensive literature search on the efficacy of ST as a first-line therapy. The odds ratios (ORs) of eradicating H. pylori infection after ST compared with TT were pooled. Pooled estimates of the eradication rates of ST and TT were also calculated. RESULTS: A total of six studies provided data on 1,759 adult patients. The ORs for the intention to treat (ITT) and the per-protocol (PP) eradication rate were 1.761 (95% confidence interval [CI], 1.403 to 2.209) and 1.966 (95% CI, 1.489 to 2.595). Pooled estimates of the ITT and PP eradication rate were 79.4% (95% CI, 76.3% to 82.2%) and 86.4% (95% CI, 83.5% to 88.8%), respectively, for the ST group, and 68.2% (95% CI, 62.1% to 73.8%) and 78.9% (95% CI, 68.9% to 81.7%), respectively, for the TT group. CONCLUSIONS: Although ST presented a higher eradication rate than TT in Korea, the pooled eradication rates were lower than expected. Further studies are needed to validate ST as a first-line treatment for H. pylori in Korea.
