Expression of IL-33,IL-37 in human nasal polyps and clinical signifi-cance
- VernacularTitle:白介素-33、白介素-37在鼻息肉组织中的表达及意义
- Author:
Junfang XUE
1
;
Xiangbin I CHA
Author Information
1. 山西医科大学第一临床医学院耳鼻咽喉头颈外科
- Keywords:
Nasal polyps;
IL-33;
IL-37;
Immunohistochemical
- From:
China Modern Doctor
2015;(12):9-11,15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of IL-33,IL-37 in nasal polyps tissue,and their relevance to the pathogenesis of human nasal polyps. Methods Immunohistochemistry was used to detect the expression of IL-33,IL-37, in excisional nasal polyps tissue from 40 patients with nasal polyps. In addition,the expression of IL-33,IL-37 was also detected in normal nasal mucosa from 18 patients with the nasal septum deviation. Results In the nasal polyps tissues,IL-33 positive rate was 65.0%,IL-37 positive rate was 20.0%.In the normal nasal mucosa, IL-33 positive rate was 33.3%,IL-37 positive rate was 77.8%. Conclusion IL-33 and IL-37 play an important role in the pathogenesis of nasal polyps.
