The expression and its significance of Notch1-3 protein in lymphoma
- VernacularTitle:Notch1、Notch2、Notch3跨膜受体蛋白在淋巴瘤组织中的表达及意义
- Author:
Hongyan XING
1
;
Qingliang TENG
Author Information
1. 青岛大学医学院
- Keywords:
Notch;
Lymphoma
- From:
China Modern Doctor
2015;(12):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and its significance of Notch1、Notch2、Notch3 transmembrane receptor protein in different types of lymphoma tissues. Methods By employing immunohistochenistry SP staining,the expres-sions of Notch in 59 lymphomas were detected, and 21 cases of lymph-node reactive hyperplasia served as control group. Results The expression of Notch1 was significantly higher in T-cell lymphoma and NK/T-cell lymphoma than that in the B-cell lymphoma and the control group, the difference was statistically significant (P<0.01). The expres-sion of Notch2 was obviously higher in B-cell lymphoma and NK/T-cell lymphoma than that in the T-cell lymphoma and the control group,the difference was statistically significant(P<0.01). The expression of Notch3 in NK/T-cell lym-phoma group was significantly higher than that in the other three groups,the difference was statistically significant (P<0.01). Conclusion Abnormal activation of Notch signaling pathway is closely related to the occurrence and develop-ment of lymphoma. The occurrence and development of NK/T-cell lymphoma is probably associated with the high ex-pression of Notch1, Notch2 and Notch3; The occurrence and development of T- cell lymphoma is probably related to the high expression of Notch1; The occurrence and development of B-cell lymphoma is probably associated with the high expression of Notch2.
