Clinical effect and safety of montelukast for the improvement of pul-monary functions and airway inflammation in children patients with bronchial asthma
- VernacularTitle:孟鲁司特钠改善小儿支气管哮喘患者肺功能和气道炎症的临床疗效与安全性
- Author:
Feng WU
1
;
Dufei ZHANG
Author Information
1. 浙江省三门县人民医院儿科
- Keywords:
Montelukast;
Bronchial asthma;
Pulmonary functions;
Airway inflammation
- From:
China Modern Doctor
2015;(11):105-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of montelukast for improving pulmonary functions and airway inflammation in children patients with bronchial asthma. Methods A total of 108 children patients with bronchial asthma who were admitted to our hospital were assigned to research group and control group based on their disease conditions. The re-search group was given regular treatment and montelukast, and the control group was given regular treatment alone. Ex-amination of pulmonary functions (FEV1, FEV1/FVC and ratio of FEV1 to predicting value), changes of airway inflamma-tion factors (IL-5, IL-10 and TNF-α), eosnophils count and clinical effects before and after the treatment between the two groups of children patients were assessed. Results The differences of indices such as FEV1, FEV1/FVC and ratio of FEV1 to predicting value in the research group after the treatment were all statistically significant compared with those in the control group(P<0.05). The differences of IL-5, IL-10 and TNF-α in the research group after the treat-ment were statistically significant compared with those in the control group (P<0.05). EOS% was (4.29±1.03)% in the research group after the treatment, and the difference was statistically significant compared with that of (5.98±1.25)%in the control group (P<0.05). 79.6%of patients in the research group received an effective treatment of bronchial asthma, and the difference was statistically significant compared with that of 29.6% in the control group (P<0.05). Con-clusion Montelukast is effective in improving pulmonary functions and airway inflammation in children patients with bronchial asthma, which is worthy of clinical promotion and application.
