Correlation of transforming growth factor β1 and interleukin 17 with al-lergic conjunctivitis
- VernacularTitle:转化生长因子β1和白细胞介素17与变应性结膜炎相关性研究
- Author:
Wenlin LI
1
;
Aiqun HE
;
Xiao ZHUO
;
Haibo LIN
;
Mudan CHEN
Author Information
1. 深圳市龙华新区中心医院眼科
- Keywords:
TGF-β1;
IL-17;
Allergic conjunctivitis
- From:
China Modern Doctor
2015;(11):69-71
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression level of transforming growth factorβ1 (TGF-β1) and interleukin 17 (IL-17) in patients with allergic conjunctivitis. Methods TGF-β1 and IL-17 expression levels in allergic conjunctivitis patients hospitalized in the author's hospital and a healthy population were detected to explore the expression level in all types of patients with allergic conjunctivitis. Results TGF-β1 and IL-17 levels were significantly higher in patients with allergic conjunctivitis than in healthy population (P<0.01). Among the four clinical subtypes of allergic conjunctivi-tis, vernal keratoconjunctivitis had the highest expression level of TGF-β1 and IL-17 in spring, followed by perennial allergic conjunctivitis and seasonal allergic conjunctivitis, and atopic keratoconjunctivitis had the lowest expression level. However, the differences among the four subtypes were not significant (P>0.05). Conclusion Patients with allergic conjunctivitis have higher TGF-β1 and IL-17 expression levels than normal healthy people. TGF-β1 and IL-17 ex-pression level vary in different subtypes of allergic conjunctivitis, vernal keratoconjunctivitis has higher expression level than other types in spring.
