What Is the Most Effective Drug Delivery System for Cisplatin during the Treatment of Hepatic Tumors with Single-Session Transcatheter Chemotherapy? A Pilot Study.
- Author:
Yusuke KAWAMURA
1
;
Kenji IKEDA
;
Taito FUKUSHIMA
;
Yuya SEKO
;
Tasuku HARA
;
Hitomi SEZAKI
;
Tetsuya HOSAKA
;
Norio AKUTA
;
Masahiro KOBAYASHI
;
Satoshi SAITOH
;
Fumitaka SUZUKI
;
Yoshiyuki SUZUKI
;
Yasuji ARASE
;
Hiromitsu KUMADA
Author Information
1. Department of Hepatology, Toranomon Hospital, Tokyo, Japan. k-yusuke@toranomon.gr.jp
- Publication Type:Original Article
- Keywords:
Cisplatin;
Attention;
Carcinoma, hepatocellular;
Drug delivery
- MeSH:
Carcinoma, Hepatocellular;
Cisplatin;
Drainage;
Drug Delivery Systems;
Ethiodized Oil;
Gelatin;
Hepatic Veins;
Humans;
Liver;
Pilot Projects
- From:Gut and Liver
2013;7(5):576-584
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: The aim of this study was to determine the pharmacodynamics of cisplatin following three different treatment procedures for intrahepatic arterial infusion therapy for hepatocellular carcinoma (HCC). METHODS: We divided 13 HCC patients into the following three groups: group A, lone injection of cisplatin (n=3); group B, combined injection of cisplatin and lipiodol, with embolization using small gelatin cubes (GCs) (n=5); and group C, injection of suspended lipiodol with cisplatin powder, with embolization using small GCs (n=5). In each group, the free cisplatin concentration in the hepatic vein was measured at 0, 5, 10, and 30 minutes. RESULTS: The mean free cisplatin concentrations were as follows. For group A, the mean was 48.58 microg/mL at 0 minute, 7.31 microg/mL at 5 minutes, 5.70 microg/mL at 10 minutes, and 7.15 microg/mL at 30 minutes. For the same time points, for group B, the concentrations were 8.66, 4.23, 3.22, and 1.65 microg/mL, respectively, and for group C, the concentrations were 4.81, 2.61, 2.52, and 1.75 microg/mL, respectively. The mean area under the curve (AUC)0-infinity for the free cisplatin concentration was 7.80 in group A, 2.48 in group B, and 2.27 in group C. The AUC0-infinity for the free cisplatin concentration gradually decreased, from group A to group C. CONCLUSIONS: These results indicate that the combination of lipiodol and small GCs may be useful for delaying cisplatin drainage from the liver.
