Serum IL-13, TGF-β1, IL-8 levels in idiopathic pulmonary fibrosis and correlation with lung function
- VernacularTitle:特发性肺纤维化患者血清IL-13、TGF-β1、IL-8水平及与肺功能的相关性
- Author:
Yu LIANG
1
;
Lingxiu JIANG
;
Wenjing QIN
;
Yuanying SHAN
;
Derong MENG
Author Information
1. 河南大学第一附属医院呼吸内科
- Keywords:
Idiopathic pulmonary fibrosis;
Serum;
IL-13;
TGF-β1;
IL-8
- From:
China Modern Doctor
2015;(11):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss serum IL-13, TGF-β1, IL-8 levels in idiopathic pulmonary fibrosis and correlation with lung function. Methods A total of 60 cases with idiopathic pulmonary fibrosis were selected as pulmonary fibrosis group, and 60 healthy volunteers were selected as control group. Serum IL-13, TGF-β1, IL-8, arterial blood gas analy-sis and related indicators of lung function were detected. Results Serum IL-13, TGF-β1, IL-8 levels of idiopathic pul-monary fibrosis group were higher than the control group(P<0.01). TGF-β1, IL-8 were significantly negative correlation with FVC predicted percentage (P<0.01); TGF-β1, IL-13 were significantly negative correlation with FEV1 predicted percentage (P<0.01); TGF-β1 and PaO2 was significantly negative correlation, and TGF-β1, IL-8 were significantly positive correlation with P(A-a)O2 (P<0.01);IL-8 was significantly negative correlation with PaO2 and SaO2 (P<0.01). Conclusion Serum IL-13, TGF-β1, IL-8 levels in idiopathic pulmonary fibrosis increase significantly, and are nega-tive correlation with lung function.
