CXCR4-mediated anti-apoptotic mechanism of gastric cancer cells
- VernacularTitle:CXCR4介导胃癌细胞的抗凋亡机制的研究进展
- Author:
Junpeng DUAN
1
;
Jian SONG
;
Xianying FAN
;
Xiaolong FAN
;
Shengli DONG
Author Information
1. 山西医科大学第二临床医院普外科
- Keywords:
CXCL12-CXCR4;
PI3K/Akt;
Gastric cancer;
Antiapoptotic
- From:
China Modern Doctor
2015;(10):156-160
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer among the world's most common malignant tumor in the fourth, the incidence of the previ-ous decline, but around the world the number of gastric cancer cases occur in China accounted for 42%, ranked the first to east Asia common types of cancer[1] At present,the stomach cancer patients can choose chemical treatment and surgical treatment, but the 5-year survival rate in 50%, cause its one of the leading causes of death are invasion and metastasis of carcinoma tissue [2] Visible, understand the occurrence, invasion and metastasis of gastric cancer related regulation and carries on the early prediction and early intervention, and to develop treatment, improve patient out-come is very beneficial. The study found that high mature gastric cancer cells expressing CXCR4, under the action of chemokines SDF-1 promote the activation of PI3K/Akt pathway in gastric cancer cells,so as to promote antiapoptotic effect of gastric cancer cells. In this paper,the high expression of CXCR4 and chemotactic factor CXCL12 signal shaft impact on PI3K/Akt pathway in gastric cancer cells and expression are reviewed.
