Influence of laparoscopic gastric cancer radical operation and open oper-ation on the function of blood coagulation and immune function in pa-tients with gastric cancer
- VernacularTitle:腹腔镜胃癌根治术与开腹手术对胃癌患者凝血功能及免疫功能的影响
- Author:
Shan WANG
1
;
Yaojun YU
Author Information
1. 杭州市钢铁集团公司职工医院外科
- Keywords:
Laparoscopic radical resection of gastric cancer;
Coagulation function;
Immune function;
Complication
- From:
China Modern Doctor
2015;(10):5-8,12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect on blood coagulation function and immune function in patients with gas-tric cancer by laparoscopic radical gastrectomy and open operation. Methods In our hospital from June 2011 to June 2014,selected hospitalized patients with gastric cancer 30 cases as the research object,15 cases were undergone tradi-tional open operation in patients with the establishment of the control group, the remaining 15 cases received laparo-scopic radical resection of gastric cancer,set up the observation group,the changes of the TT,APTT,INR,FIB,D-D of blood coagulation indexes of two groups were compared,and changes in two groups of patients with immune function indexes of CD3+,CD4+,CD8+,CD4+/CD8+,and the operation time,bleeding amount of two groups of operation,ambula-tion time, hospital stay, postoperative complications were compared between two groups. Results In the observation group and the control group after 24 h,the FIB,D-D was significantly higher than the preoperative,and the observa-tion group patients after operation significantly were higher than the control group (P<0.05). After operation 1 weeks,CD3+,CD4+, CD8+, CD4+/CD8+of observation group showed no significant changes (P>0.05). CD3+, CD4+, CD4+/CD8+of control group after 1 weeks significantly changed compared with the preoperative, and CD3+, CD4+, CD4+/CD8+ of observation group compared with the control group,the difference was statistically significant(P<0.05). But CD8+of the control group had no obvious change before and after surgery(P>0.05). The observation group patients' out of bed activity time, postoperative hospitalization time was significantly shorter than that in the control group,the amount of bleeding observation group was significantly less than that the control group(P<0.05). Conclusion Laparoscopic radical gastrectomy for gastric cancer curative has good effect, compared with open radical gastrectomy for gastric cancer with less bleed-ing, fewer complications, patients recovered quickly, the advantages of immune function in patients with small inter-ference, but the effects of laparoscopic operation on blood coagulation in patients with more significant, corresponding measures should be taken to prevent the formation of thrombus coagulation abnormalities caused by postoperative.
