The advance of thymidylate synthase and thymidine phosphorylase in the metastatic gastric cancer
- VernacularTitle:胸苷酸合酶和胸苷酸磷化酶在进展期胃癌中的研究进展
- Author:
Dongming ZHANG
1
;
Mingzhang LI
;
Haifeng WU
;
Jun MA
Author Information
1. 内蒙古自治区包头市中心医院普外科
- Keywords:
Gastric cancer;
Thymidylate synthase;
Thymidylate phosphorylase;
Chemotherapy;
5-fluorouracil
- From:
China Modern Doctor
2015;(3):158-160
- CountryChina
- Language:Chinese
-
Abstract:
5-fluorouracil (5-Fu) is a basic drug in the treatment of advanced gastric cancer. It is widely used in chemotherapy regimens for metastatic gastric cancer. However, the reaction rate was only 10%~30% when used 5-Fu alone. Interindividual variation in the enzyme activity of the 5-Fu metabolic pathway can affect the metabolism extent of 5-Fu and the efficacy of chemotherapy based on 5-Fu. In this review the roles of thymidylate synthase and thymi-dine phosphorylase enzymes factors involved in the 5-Fu metabolic pathway and the efficacy of fluoropyrimidine treat-ment in the metastatic gastric cancer are discussed.
