The clinical research of sodium nitroprusside combined with hy-drochlorothiazide on chronic heart failure
- VernacularTitle:硝普钠联合氢氯噻嗪治疗慢性心力衰竭的临床研究
- Author:
Danfeng KE
1
;
Gonghua PAN
;
Qiqi WANG
Author Information
1. 浙江省玉环县第二人民医院急诊科
- Keywords:
Chronic heart failure;
Sodium nitroprusside;
Hydrochlorothiazide
- From:
China Modern Doctor
2015;(3):107-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of sodium nitroprusside combined with hydrochlorothiazide in the treat-ment of chronic heart failure. Methods The 100 cases of patients with chronic heart failure were selected from August 2012 to October 2013, and they were randomly divided into experimental group (50 cases) and control group (50 cases), control group was given conventional treatment (beta blockers, angiotensin converting enzyme inhibitors, myocardial nutrition and digitalis drugs), the treatment on the basis of conventional combined with sodium nitroprusside, hy-drochlorothiazide was applied in experimental group, by echocardiography through two experimental groups and control group before and after treatment in patients with left ventricular ejection fraction (LVEF) and left ventricular end-dias-tolic diameter (LVDD), laboratory testing in patients with myocardial troponin (cTnT), high C-reactive protein (CRP), tumor necrosis factor alpha (TNF alpha) content, USES the heart function evaluation standards promulgated by the New York heart association, the curative effect of patients in two groups was judged. Results Compared with the patients in control group after treatment, blood pressure, heart function LVEF, LVDD, CRP, cTnT and TNF alpha of experimental group improved, 6 minutes walk test distance was longer, the total effective rate, the efficiency was improved, statistical significance was founded between two groups (P<0.05). Conclusion The effect of sodium nitroprusside combined with hy-drochlorothiazide on patients with chronic heart failure curative is distinct, worth clinical promotion.
