Improvement effect of butylphthalide soft capsules on cognitive function of patients with cerebral arterial thrombosis in recovery period
- VernacularTitle:丁苯酞软胶囊对缺血性脑卒中恢复期患者认知功能的改善作用
- Author:
Shuming HONG
1
;
Songfang CHEN
Author Information
1. 浙江省浦江第二医院神经内科
- Keywords:
Cerebral arterial thrombosis in recovery period;
Butylphthalide;
Cognitive function
- From:
China Modern Doctor
2015;(3):101-103
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss improvement effect of butylphthalide soft capsules on cognitive function of patients with cerebral arterial thrombosis in recovery period. Methods A total of 86 cases of patients with cerebral arterial thrombosis in recovery period were divided into observation group and control group at random. The patients in two groups were given the basic medical treatment such like depressurization, glucose-lowering, lipid-regulating, anti-platelet aggregation, cerebral circulation improvement and etc. The patients in observation group were additionally given butylphthalide soft capsules, 0.2 g per time, three times a day, while the patients in control group were additionally given piracetam tablets, 1.2 g per time, three times a day for 14 days. The changes of cognitive function indexes of pa-tients in two groups before and 14 days after the medical treatment were observed, and the curative effect and security evaluation were carried on as well. Results After 14 days’ medical treatment, WMS and MOCA scores of patients in two groups were obviously rose (P<0.05 or P<0.01), and the rising rate of patients in observation group was much high-er than that in control group (P<0.05). Meanwhile, total improvement rate of cognitive function of patients in observa-tion group was 95.35%, much higher than that in control group (79.07%) (χ2=5.11, P<0.05). 8 cases of drug adverse re-action (DAR) of patients in two groups were appeared during the medical treatment, 3 cases in observation group and 5 cases in control group, with light symptom. After comparing the untoward effect of patients in two groups, no statistical differences were appeared (χ2=0.14, P>0.05). Conclusion Butylphthalide soft capsules has favorable improvement effect on the declining of cognitive function of patients with cerebral arterial thrombosis in recovery period, which can en-hance the recovery of cognitive function of patients with favorable security.
