A retrospective study on the diagnostic value of serum homocystine in re-nal diseases
- VernacularTitle:同型半胱氨酸在肾脏疾病中检测的意义
- Author:
Chan GAO
1
;
Ming WANG
;
Xiao FEI
;
Qunhong XU
;
Ning ZHAO
Author Information
1. 杭州市第一人民医院肾脏内科
- Keywords:
Homocystine;
Renal diseases;
Early diagnose
- From:
China Modern Doctor
2015;(3):23-25,28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of serum homocystine (HCY) in renal diseases. Methods Serum HCY, creatinine, urea, albumin, parathyroid hormone (PTH), β2 microglobulin were measured in 167 patients with renal disease, and the HCY was compared with those traditional index in kidney diseases with the aim to deter-mine the role of HCY played in renal diseases. Results With the decreasing of glomerular filtration rate (GFR), the serum HCY level increased correspondingly. Compared with normal control group, there were statistically significant differences in the serum HCY when the GFR was below 90 mL/(min·1.73 m2).HCY was positively correlated with cre-atinine, urea, PTH and β2 microglobulin (P<0.05); negatively correlated with endogenous creatinine clearance rate (Ccr) (P<0.05). Conclusion HCY may be an important indicator for early diagnosis of the impairment of renal function in renal diseases. It can be used to indicate the degree of severity of renal impairment in patients with nephropathy.
