Influence and curative effect observation of intensive lipid-lowering on serum interleukin-6, 8 and 10 ﹙IL-6, 8 and 10) levels of patients with cerebral arterial thrombosis
- VernacularTitle:强化降脂对缺血性脑卒中患者血清白介素-6、8和10水平的影响及疗效观察
- Author:
Weiqiang WANG
1
;
Lifei LUO
Author Information
1. 浙江省临海市第二人民医院急诊科
- Keywords:
Cerebral arterial thrombosis;
Intensive lipid-lowering;
Interleukin-6;
Interleukin-8;
Interleukin-10
- From:
China Modern Doctor
2015;(2):76-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the influence and curative effect of intensive lipid-lowering on serum Interleukin-6, 8 and 10﹙IL-6, 8 and 10) levels of patients with cerebral arterial thrombosis. Methods A total of 88 cases of patients with cerebral arterial thrombosis were selected and divided into intensive group ﹙n=44) and ordinary group ﹙n=44) at random. The patients in two groups were promptly given routine lowering intracranial pressure, control of blood pres-sure and blood sugar, anti-platelet aggregation, brain cells nutrition and other medical treatment. The patients in ordi-nary group were additionally given Atorvastatin tablets through the mouth, 20 mg per time, once a day, and the patients in intensive group were additionally given Atorvastatin tablets through the mouth, 40 mg per time, once a day for 4 weeks. The changes of serum IL-6, 8 and 10 levels of patients in two groups before and 2 or 4 weeks after medical treatment were observed and recorded, and the clinical curative effect and drug adverse reaction﹙DAR) were compared as well. Results After 2 or 4 weeks’medical treatment, the serum IL-6 and 8 levels of patients in two groups obviously declined than before, while the IL-10 levels obviously rose than before ﹙P<0.05 or P<0.01), and the declining or rising rates of patients in intensive group were much higher than those in ordinary group ﹙P<0.05). Meanwhile, the total clinical efficiency of patients in intensive group was much higher than that in ordinary group after 2 or 4 weeks’medi-cal treatment ﹙χ2=5.09, P<0.05). No obvious DAR appeared on patients in two groups during the medical treatment. Conclusion Atorvastatin intensive lipid-lowering has reliable curative effect on cerebral arterial thrombosis with high security, whose mechanism of action has close effect on reducing the serum IL-6 and 8 levels, raising serum IL-10 level, adjusting the serum inflammatory cytokines network disorder.
