Effects of the concentrated quercetin on the red blood cells of patients lacking G6PD
- VernacularTitle:高浓度槲皮素对G6PD缺乏者体外红细胞的影响
- Author:
Jintao DONG
1
;
Li CHEN
;
Lihong LIANG
Author Information
1. 广州市白云区第一人民医院儿科
- Keywords:
High concentration of quercetin;
G6PD deficiency;
Red blood cell
- From:
China Modern Doctor
2015;(2):17-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of high concentrated quercetin on red blood cells in vitro of patients lacking G6PD. Methods A total of 50 cases whose G6PD activity were normal and 50 cases who lacked G6PD were selected. Peripheral blood was collected and incubated with quercetin to test the erythrocyte GSH and MetHb and the morpho-logical changes of red blood cells was observed. The effects of quercetin on erythrocyte of patients lacking G6PD activ-ity were investigated. Results Quercetin had obvious effect on the oxidation of erythrocytes of patients lacking in G6PD and the patients' GSH decreased but their MetHb increased significantly (P<0.05). The MetHb in the high concentra-tion group was (5.70±2.03)%, which was significantly higher than that in medium and low concentration groups (3.51± 1.67)%,(1.31±0.68)%. The difference was statistical significant(P<0.05). The effect of alpha naphtha on the patients in deficiency group and the normal group had obvious differences, but the performance of alpha naphthol in the 2 in-cubation system at the presence was different. Conclusion The effect of quercetin on red blood cells of erythrocyte of patients lacking G6PD have some adduction. So it could be cautious when the compounds preparation containing oxidiz-ing falconoid is used.
