Current study on the podocyte phenotypic transformation of diabetic nephropathy and its medical intervention
- VernacularTitle:糖尿病肾病的足细胞表型转化及其干预研究现状
- Author:
Pengchao HOU
1
;
Yuzhi HONG
;
Xun YE
Author Information
1. 浙江中医药大学
- Keywords:
Diabetic nephropathy;
Podocyte;
Phenotypic transformation;
Valsartan;
Triptolide
- From:
China Modern Doctor
2014;(35):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy (DN) is one of the most common and severe complications of diabetic microangiopa-thy which gradually become the major cause of end-stage renal disease (ESRD) in recent years, even though its patho-genesis remains to be elucidated. Proteinuria is one of important malignant factors leading to the deterioration of DN as well as its mainly clinical feature. Lately experimental evidences show that podocyte phenotypic transformation could be a causative role in the genesis of the early DN proteinuria. In this context, it ’s necessary to review the relative bio-logical characteristics of podocyte phenotypic transformation, its associated signaling pathways, its relationship between proteinuria and the possible mechanism of its medical intervention including valsartan and triptolide.
