Investigation of the role of HIF-1α and VEGF in women with missed abortion
- VernacularTitle:HIF-1α与VEGF在稽留流产组织中的表达及意义
- Author:
Yanli LI
1
;
Lili YANG
;
Han GAO
;
Yichong YUAN
;
Faxia ZHU
;
Bin YAN
;
Xufeng WU
Author Information
1. 湖北省妇幼保健院妇科Ⅱ
- Keywords:
Missed abortion;
HIF-1α;
VEGF
- From:
China Modern Doctor
2014;(35):127-129,132
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of HIF-1αand VEGF signaling in missed abortion. Methods Fifty patients with missed abortion were selected as study group, and fifty early pregnant women who underwent artificial abortion surgery were selected as control group. The expressions of HIF-1α and VEGF were measured by immunohis-tochemistry. Results The expressive rate of VEGF was 100%in the control group and 66% in the study group. The ex-pressive rate of HIF-1α was 42% in the control group and 76% in the study group. Compared with the control group, the expression of VEGF was statistically reduced(P<0.05) while the level of HIF-1α was significantly up-regulated(P<0.05)in the study group. In the control group, HIF-1αwas positively correlated with VEGF(r=0.387,P<0.05), while in the study group HIF-1α was close negatively correlated with VEGF(r=-0.298,P>0.05). Conclusion The decrease of VEGF and increase of HIF-1αin villous trophoblastic cells may be signals of occurrence of missed abortion.
