Clinical pathological analysis study of ten solitary fibrous tumors
- VernacularTitle:10例孤立性纤维性肿瘤临床病理学研究
- Author:
Lihua LUO
1
;
Wanyi ZHANG
;
Jun RUAN
;
Jianchu CHEN
;
Bingquan LI
Author Information
1. 广东省清远市人民医院病理科
- Keywords:
Solitary fibrous tumor;
Immunohistochemistry;
CD34;
Bcl-2;
Differential diagnosis
- From:
China Modern Doctor
2014;(35):56-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze solitary fibrous tumor (solitary fibrous tumor, SFT) ’s clinical manifestations, patholog-ical features, immunohistochemical phenotype, and follow-up, discuss the diagnosis, differential diagnosis and progno-sis. Methods Ten cases of SFT were analyzed by clinical data and follow-pathological characteristics study and im-munohistochemical staining of Vimentin, CD34, Bcl-2, CD99, SMA and β-catenin. Results There were 6 males and 4 females with ranging in age from 31 to 78 years (mean 53.2 years old). SFT in four cases originated from the visceral pleura, two cases from parietal pleura,one from the skin of the chest wall, one from the neck, one from the medi-astinum, one from subcutaneously. Microscopic examination of tumor tissue was mainly composed of spindle cells, dif-ferent levels of visible cells and cell-rich areas of sparse areas, tumor cells were short spindle or oval, mitotic due to the severity varies. During the visible rich collagen fibers, may be associated with hyaline degeneration or myxoid change. Immunohistochemistry revealed the tumor cells expessed Vimentin, CD34, Bcl-2, CD99 and β-catenin, SMA focal or weakly positive. Conclusion SFT may occur in various sites of the body. The clinicopathological features and immunohistochemical profile are helpful to identify SFT. Its biological behavior is consistent with its histological mor-phology and growth the way. If tumor could be removed completely, the patients may have a good prognosis;some have low-grade malignant or malignant behaviour, manifesting as local recurrence or metastasis. Patients need long-term follow-up.
