Expression of livin genes in colon cancer tissues chip and its correlation with bcl-2 genes
- VernacularTitle:Livin基因在结肠癌组织芯片中的表达及其与Bcl-2相关性研究
- Author:
Haibo LI
1
;
Shengliang CHI
Author Information
1. 浙江省台州市肿瘤医院普外科
- Keywords:
Colon cancer;
Immunohistochemical;
Livin genes;
Pathological characteristics
- From:
China Modern Doctor
2014;(35):21-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss expression of livin genes in colon cancer tissues chip and its correlation with Bcl-2 genes. Methods A total of 60 cases of patients with colon cancer, who chose to be treated with surgical operation in General Surgery Department were selected, and applied with immunohistochemical MaxVisionTM two step method to detect the expression of livin and Bcl-2 genesn in tissues chip. 25 cases of colon tissues chip with normal cutting edge were additionally chosen as control group. Results Positive livin genes expression rates in colon cancer tissues chip (63.33%) were much higher than those in colon tissues with normal cutting edge, which appeared statistical differences (24.00%) (χ2=10.93, P<0.01). Livin genes expression in colon cancer tissues chip had no obvious relevance with gen-der, age, tumor size, differentiation degree, lymphatic metastasis and other pathological characteristics (P>0.05), but ob-vious relevance with invasive depth, Duke’s stages, distant metastasis and other pathological characteristics (P<0.05 or P<0.01). Positive Bcl-2 genes expression rates in colon cancer tissues chip (68.33%)were much higher than those in colon tissues with normal cutting edge, which appeared statistical differences (4.00%) (χ2=29.22, P<0.01). Livin genes expres-sion was positively relatedto Bcl-2 genes in expression in colon cancer tissues chip (P<0.01). The invasive depth, Duke’s stages and distant metastasis were included in meta stasis of dinthe Logistic regression model for livin genes expression (P<0.05). Conclusion Livin genes play important roles in the disease process of colon cancer tissues chip and have close relevance with pathologic process of malignant invasion and transfer of tumor. The expression of Livin genes and Bcl-2 genes may play synergetic roles in process of colon cancer.
