Analysis of the clinical value of MCV combined with Hb electrophoresis in detection of thalassemia
- VernacularTitle:地中海贫血筛查中MCV和Hb电泳联合检测的临床价值分析
- Author:
Chunlong LI
1
;
Danjian YUAN
;
Changhong WU
;
Hui MA
;
Yuqian LIU
Author Information
1. 深圳市盐田区妇幼保健院检验科
- Keywords:
Thalassemia;
MCV;
Hb electrophoresis
- From:
China Modern Doctor
2014;(30):61-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of MCV combined with Hb electrophoresis in detection of tha-lassemia. Methods Selected 150 cases of patients with thalassemia as the observation group, and other 150 cases of non-thalassemia patients were selected in our hospital as control group. MCV and Hb electrophoresis examination were conducted in two groups of patients, and the positive rates were recorded. And then we analyzed the specificity and sensitivity of the two methods as well as the combined examination. Results In the single MCV or Hb electrophoresis detection, the positive rate in observation group patients was higher than this in the control group, and the differences were statistically significant (P<0.05). The sensitivity and specificity of MCV detection were separately 91.33% and 76.67%, and the sensitivity and specificity of Hb electrophoresis were separately 85.33% and 79.67%. And when we conducted the combined detection, the sensitivity decreased, but the specificity increased. Conclusion For the patients with thalassemia, by using the method of MCV combined with Hb electrophoresis, we can improve the specificity in de-tection of disease. It is worthy of promotion in clinical use.
