Recombinant acidic fibroblast growth factor combined with negative pressure drainage in treatment of recalcitrant wounds
- VernacularTitle:重组酸性成纤维细胞生长因子持续冲洗合并负压引流治疗难愈性创面
- Author:
Gang LI
1
;
Xiaobing LI
;
Zijian LIU
;
Guangjing LIU
;
Jingqi ZHANG
;
Shuang WANG
Author Information
1. 天津市第一中心医院整形与烧伤外科
- Keywords:
Recombinant human acidic fibroblast growth factor;
Refractory wound;
Negative pressure drainage;
Flaps transplantation
- From:
China Modern Doctor
2014;(30):10-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective Study the effect of recombinant human acidic fibroblast growth factor combined suction drainage in the treatment of refractory wound. Methods Fifty-four patients with refractory wound were analyzed from January 2010 to December 2012 and were randomly divided into the treatment group (n=29, treated with rh-aFGF washing dur-ing operation) and control group (n=25, treated with 0.9% NS). Both groups were treated combined suction drainage treatment. Exposed areas of surface and deep tissue were recorded during the treatment, then the rate of deep wound healing and the rate of cavity volume improvement were calculated. Results Wound in the treatment group cured pri-marily, and the area of bone tendons exposure reduced. The rate of deep wound healing and the rate of cavity volume improvement in the treatment group were better than the control group (P<0.05). The treatment group all healed after short time dressing change. However, the control group all healed after long time dressing change or with skin flap transplantation. Conclusion By exogenous long-term supplementing aFGF and it can achieve the purpose of therapy.
