Efficacy observation of chemohyperthermia in treatment of ovarian can-cer combined with peritoneal effusion
- VernacularTitle:热灌注化疗治疗卵巢癌合并腹腔积液疗效观察
- Author:
Liya ZHANG
1
;
Aiwen ZHENG
Author Information
1. 浙江省海宁市中医院妇产科
- Keywords:
Ovarian cancer;
Peritoneal effusion;
Chemohyperthermia;
Clinical efficacy
- From:
China Modern Doctor
2014;(29):146-148,151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of chemohyperthermia in the treatment of ovarian cancer com-bined with peritoneal effusion. Methods Forty patients with ovarian cancer combined with peritoneal effusion treated in our hospital from January 2006 to January 2013 were selected as the study subjects and randomly divided into the study group and the control group according to the random number method, with 20 patients in each group. All the pa-tients once went through surgical treatment, were diagnosed with epithelial ovarian cancer, received postoperative chemotherapy, had uncontrolled or recurrent tumor, and were complicated by peritoneal effusion. The control group was given conventional whole body chemotherapy and the study group was given intraperitoneal chemohyperthermia com-bined with whole body chemotherapy. The clinical efficacy of the two groups was observed. Results The study group had significantly higher treatment effective rate and life quality score than the control group (P<0.05), with statistical significance. Neither group had severe toxic nor side reactions; The existing toxic and side reactions were mild and re-mitted after symptomatic treatment. The 1-year survival rate of the study group was 85.0%and that of the control group was 65.0%. The study group had significantly higher 1-year survival rate than the control group(P<0.05), with statistical significance. Conclusion It is feasible to provide chemohyperthermia to the patients with ovarian cancer combined with peritoneal effusion and it can effectively improve the clinical efficacy and life quality, which is worthy of clinical appli-cation.
