Effect of CIK cells immunotherapy on immunological function of patients with metastatic renal cell carcinoma
- VernacularTitle:CIK细胞免疫治疗对转移性肾细胞癌患者免疫功能的影响
- Author:
Hongquan CUI
1
;
Junfeng ZHAO
;
Baodong LI
;
Linchao ZHANG
Author Information
1. 河南省中医院泌尿外科
- Keywords:
CIK cells;
Metastatic renal cell carcinoma;
Immunological function
- From:
China Modern Doctor
2014;(29):132-133,136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of cytokine-induced killer(CIK) cells immunotherapy on immunological func-tion of patients with metastatic renal cell carcinoma.Methods A total of 70 patients with metastatic renal cell carcino-ma were randomly divided into 2 groups, 35 cases of the treatment group were added with CIK cells, while the control group was given IL-2 and IFN-α, detected the immunological function of 70 cases including the levels of CD3+, CD4+, CD8+T cells, ratio of CD4+/CD8+, one week before therapy of CIK cells and one month week after treatment. Results The levels of CD3+、CD4+cells, ratio of CD4+/CD8+in peripheral blood of patients with renal cancer of two groups were much higher than those before therapy (P<0.05), the levels CD8+ was lower after treatment, there were significant changes (P<0.05). Conclusion CIK cells immunotherapy can enhance the immunological function of patients with meta-static renal cell carcinoma.
