Case control study for impact of sevoflurane and propofol -control study in elderly patients undergoing abdominal postoperative cognitive function
- VernacularTitle:七氟烷与丙泊酚对老年腹部手术患者术后认知功能影响的对照研究
- Author:
Jihui HE
1
;
Li WANG
Author Information
1. 杭州钢铁集团公司职工医院麻醉科
- Keywords:
Sevoflurane;
Propofol;
Postoperative cognitive dysfunction;
S100βprotein
- From:
China Modern Doctor
2014;(29):31-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study sevoflurane and propofol for abdominal surgery in elderly patients with general anesthe-sia on postoperative cognitive function. Methods A total of 146 elderly patients with abdominal surgery were randomly divided into group A and group B, each of 73 cases, respectively, used sevoflurane and propofol anesthesia maintained. Results Set of recovery time, extubation time in group A were significantly less than group B (P<0.05). Group A and group B after 2 h, 6 h, 12 h MMSE were significantly lower than the preoperative (P<0.05), after 24 h, 48 h normal cognitive status, after 2 h, 6 h, 12 h MMSE in group B were significantly higher than those in group A(P<0.05). A group and B group before and after surgery 2 h, 24 h after serum S100βprotein, IL-2 levels after 2h before surgery were sig-nificantly higher than preoperative (P<0.05), 24 h after the fall, group B after 2 h serum S100β protein, IL-2 levels were significantly lower than group A (P<0.05). Conclusion Sevoflurane and propofol for abdominal surgery under general anesthesia in elderly patients with varying degrees of reversibility may cause postoperative cognitive dysfunc-tion, can be quickly restored, the degree of dysfunction induced by sevoflurane cognitive heavier, postoperative cogni-tive dysfunction and serum S100βprotein, IL-2 increases related.
