Comparison of the diagnosis value of neutrophil CD64 and CRP as a sin-gle test for the early detection of neonatal sepsis
- VernacularTitle:CD64指数和CRP测定对早期诊断新生儿败血症的价值对比研究
- Author:
Fang YANG
1
;
Fangfang TU
;
Wenna XIANG
;
Qidan ZENG
Author Information
1. 温州医科大学附属第三医院儿童医院新生儿科
- Keywords:
Neutrophil CD64;
C-reactive protein;
Neonatal sepsis
- From:
China Modern Doctor
2014;(29):24-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the diagnostic accuracy between neutrophil CD64 and C-reactive protein (CRP) as a single test for the early detection of neonatal sepsis. Methods A total of 36 patients who were hospitalized in neonatal intensive care unit (NICU) in our hospital were divided into documented sepsis group(n=10), clinical sepsis group (n=14) and control newborns (n=12). CRP, neutrophil CD64, complete blood counts and blood culture were detected at the time of the suspected sepsis for the documented or clinical group. CD64 was measured by automatic flow cytometry. The di-agnostic value of CRP and CD64 was assessed by receiver operating characteristic (ROC) curve analysis. Results CD64 was significantly elevated in the groups with documented or clinical sepsis, whereas CRP was not significantly increased compared with controls. For documented sepsis group, CD64 and CRP had a sensitivity of 92% and11%, a specificity of 83% and 80%, a positive predictive value of 83% and 34% and a negative predictive value of 91% and 50%, respectively, with a cutoff value of 3.2 mg/dL for CD64 and 1.1 mg/dL for CRP. Conclusion The diagnostic ac-curacy of CD64 is superior to CRP when measured at the time of suspected sepsis, which implies that CD64 is a more reliable marker for the early identification of neonatal sepsis as a single determination compared with CRP.
