Postoperative curative effect comparison of goserelin and gestrinone on endometriosis (EMT)
- VernacularTitle:戈舍瑞林与孕三烯酮用于子宫内膜异位症术后疗效比较
- Author:
Lingjun WANG
1
;
Zhimei WU
;
Jian LI
Author Information
1. 厦门长庚医院妇产科
- Keywords:
Endometriosis (EMT);
Gestrinone;
Goserelin;
Reoccurrence
- From:
China Modern Doctor
2014;(29):13-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss postoperative curative effect comparison of goserelin and gestrinone on endometriosis (EMT). Methods A total of 75 cases of patients with EMT, who were given EMT cystectomy of under laparoscopy, were divided into observation group (n=37 cases) and control group (n=38 cases) in accordance with different treatment meth-ods. The patients in observation group were given 3.6 mg goserelin by subcutaneous injection within 1 week upon the operation, once for every 4 weeks, for 6 times, while the patients in control group were given 2.5 mg gestrinone through the mouth within 1 week upon the operation, twice for every week for 48 times. According to the 2-year following-ups after treatment, the curative effect, reoccurrence rates, occurrence rates of untoward effect and pregnancy rates of pa-tients in two groups were observed. Results According to the 2-year following-ups after treatment, 4 and 2 cases of patients were lost to follow up, and after comparing the loss ratios of follow-up of patients in two groups, no statistical differences were appeared (χ2=0.15, P>0.05). The total efficiency of patients in observation group was much higher than that in control group, while the reoccurrence rate was much lower than that in control group (χ2=3.85, P<0.05). 9 and 6 cases of untoward effect were appeared in control group and observation group respectively, with light symptom, and after comparing the occurrence rates of untoward effect, no statistical differences were appeared (χ2=0.88,P>0.05). The suc-cessful pregnancy rate of patients in observation group after 2-year withdrawal of drugs was much higher than that in control group (χ2=4.69, P<0.05). Conclusion Compared with gestrinone, goserelin has more favorable postoperative cura-tive effect on EMT, which can obviously reduce the postoperative reoccurrence rate, and raise the successful pregnancy rate and higher security.
