Clinical study of serum thymidine kinase 1 in patients with gastric carci-noma pre and post-operation
- VernacularTitle:胃癌患者手术前后血清胸苷激酶1水平变化的临床研究
- Author:
Lin LIN
1
;
Qingwen XU
;
Jue LU
;
Caijin ZHOU
Author Information
1. 广东医学院附属医院胃肠外科
- Keywords:
Thymidine Kinase 1;
Gastric carcinoma;
Operation
- From:
China Modern Doctor
2014;(27):151-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the use of Thymidine Kinase 1(TK1)in serum as proliferating tumor marker for gas-tric carcinoma and monitoring marker for the response to operation. Methods Serum level of TK1 expression were de-tected with sensitive chemiluminescence dot-blot assay in were available to detect the level of serum TK1 in 35 cases of normal healthy subject and 68 cases of patients with gastric carcinoma, compared with 43 cases of patients with gastric carcinoma pre-and post-operation. Results The level of serum TK1 were elevated in all subgroups of patients with gastric carcinoma compared to the normal healthy subject(P<0.01),serum TK1 was correlated with TNM stage and histological grade,and not with sex and age; the serum TK1 level in stage Ⅳwas higher in comparison with stage Ⅲ,in stage Ⅲit was higher than that in stage II, in stage IIit was higher than that in stage Ⅰ, and in stage Ⅰit was higher than that in normal healthy subject (P<0.01-0.05); Being lower in the well differentiated and moderately dif-ferentiated than the poorly differentiated (P<0.01-0.05), the level of serum TK1 was higher in the cases of poorly differentiated adenocarcinoma, signet ring cell carcinoma and mucoid adenocarcinoma than those in the cases of well differentiated and moderately differentiated adenocarcinoma (P<0.05), the serum TK1 levels remarkably reduced in patients with gastric carcinoma after operation(P<0.01). Conclusion Detection the level of serum TK1 may be larger clini-cal value for cancer diagnosis,predict disease progression and the curative effect in patients with gastric carcinoma.
